Mucoadhesion of polyamphoteric hydrogels synthesized from acrylic acid and N,N-dimethylaminopropyl acrylamide

Bioadhesive polymeric hydrogels capable of firm adhesion to various biological tissues have acquired considerable attention due their significance in medicine and dentistry. Thus far many types bioadhesive been investigated using different polymers such as polyacrylates, poly(ethylene glycol)s, the derivatives polysaccharides proteins, while less has paid polyamphoteric properties cross-linked polymer networks. The aim this study is investigate synthesized by copolymerizing acrylic acid with N,N-dimethylaminopropyl acrylamide presence N,N′-methylenebisacrylamide. Tissue hydrated gels was evaluated vitro excised porcine intestine a substrate, data were compared that measured for pure poly(acrylic acid) hydrogel system extensively studied ever. In study, it demonstrated incorporation small fraction cationic monomer gives rise formation exhibit toward mucosa. results mechanistic revealed enhancement cation primarily increased density carboxylic acids are interacting mucosal components. Furthermore, suggested dynamic behaviors segments an additional effect on enhanced mucoadhesion.